Mesna: a novel renoprotective antioxidant in ischaemic acute renal failure
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چکیده
منابع مشابه
Mesna: a novel renoprotective antioxidant in ischaemic acute renal failure.
BACKGROUND Reactive oxygen species (ROS) play a key role in renal ischaemia-reperfusion injury. After establishing the in vitro anti-oxidative potential of mesna, a sulfhydryl-containing compound, its effect on kidney function and morphology in a rat model of ischaemic acute renal failure (ARF) was examined. METHODS Mesna (180 mg/kg) was administered at different time points relative to ischa...
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BACKGROUND Klotho is associated with the suppression of several ageing phenotypes. Because high klotho gene expression was detected in the kidney and several studies have found altered expression in animal models, we explored the physiological relevance of klotho expression in the kidney under renal ischemia reperfusion injury (IRI). METHODS Male Wistar rats were subjected to bilateral renal ...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2001
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/16.3.542